THE MAJORITY OF RABIES VICTIMS ARE CHILDREN LIVING IN RURAL AREAS

“FREE PRISHA FROM RABIES”

World Rabies Day Prisha

DYING OF A PREVENTABLE DISEASE

IS NOT ACCEPTABLE!!

EVERY YEAR, ≈ 60,000 PEOPLE DIE FROM RABIES

THE MAJORITY IN DEVELOPING COUNTRIES

 

READ THE STORY of

An EXPERT’ PERSONAL EXPERIENCE WITH RABIES VICTIMS 

IN MALAWI AND THE NETHERLANDS

 

MY FIRST CASE was back in 1980, in Malawi. I WAS ASTONISHED to experience a patient with the full clinical picture of which I have only read in study books during my medical training and that at the time seemed to be “a thing far away, I never should encounter”.

I WILL NEVER FORGET! SEEING A PREVIOUSLY HEALTHY BOY OF 10-YEARS-OLD, going through a dreadfully

short illness, which finally ended in death, for which the medical staff only could give SUPPORTIVE CARE. And, to see THE HELPLESSNESS OF HIS FATHER AND MOTHER, trying TO COMFORT THE SON as much as possible.

 

 

 

Recently, IN ALL 3 RABIES CASES, in The Netherlands, THE SAME FEELING OF HELPLESSNESS was present by family members and the medical staff involved, as the presumed treatment did not work out. Before these patients were brought into coma for treatment purpose, anxiety was present for the fact that they knew that the treatment option was unlikely to work out. For both, the family and the medical team involved, this experience had an enormous impact. Mental coaching had to be provided thereafter!

 

 

 

 

Pieter van Thiel, MD PhD

Infectious disease physician and consultant, Academic Medical Center, University of Amsterdam, The Netherlands

SOMEWHERE IN AFRICA & ASIA, PEOPLE ARE STILL DYING FROM A DISEASE THAT IS 100% PREVENTABLE, BUT 99.9% FATAL!

 

EVERY YEAR≈ 60,000 PEOPLE DIE FROM RABIES

IN FACT, ONE PERSON DIES OF RABIES EVERY 9 MINUTES

Why are so many people STILL DYING FROM A PREVENTABLE DISEASE in a time with so much technological advancement? 

We live in a world where neglected diseases seem to be acceptable…

Rabies gains little attention of the world compared to other infectious diseases, while it definitely deserves more attention since it is a preventable disease that has been around for millenia. The World Health Organization (WHO) has classified Rabies as a NEGLECTED DISEASE.

 

 

WHAT DOES IT TAKE FOR 60,000 PEOPLE TO DIE A YEAR????

A HORRIBLE TRAGEDY 

A FULL 747 CRASH (∼430 DEATHS) EVERY OTHER DAY

Men, women and innocent children who will lose their lives, on their way to their holiday destination, their homes, loved ones, or their job obligations.

THE DEATH CASES OF RABIES IS NOT DIFFERENT!

We need one such crash every other day for a year to reach the 60,000 DEATHS.

STEP 1: STOP RABIES AND START EDUCATING YOURSELF ABOUT THIS NEGLECTED DISEASE!

Why we perform rabies research

 

Reason one: Available preventive measures are too expensive

High rabies mortality in developing countries due to low vaccine usage as a result of high costs. Many of these infections could have been prevented or many infected individuals could have been helped if vaccine and antibody preparations were available at an affordable price.

Reason two: Lack of understanding in the disease mechanisms

We believe that no infectious disease that takes precious lives should be neglected! Our goal is to provide affordable solutions by understanding the way rabies virus causes disease.

Reason three: Increasing awareness

In face of the high costs associated with prophylaxis and post-exposure treatment, and the lack of symptomatic treatment, the best way to reduce unnecessary deaths is by increasing awareness about rabies and how to prevent it.

MAKE A DIFFERENCE, AND COME INTO ACTION

Help FIGHT RABIES!

  1. Rabies treatment for “ALL”

    "IMAGINE", a future where rabies is treatable.
    €815,00 donated of €60.000,00 goal
  2. Rabies vaccines and immunoglobulins: “Affordable” and accessible for the “POOR”

    "Affordable" and "accessible" interventions for the 'POOR"
    €605,00 donated of €60.000,00 goal

WE NEED YOUR HELP

Rabies vaccines and antibodies: Affordable and accessible for the poor.

What EXPERTS say

 

Understanding rabies is not a pit, it is a ladder

– Pieter van Thiel, MD.PhD

Raising awareness is a response to the rabies torment, but not responding is also a response and we are equally responsible for what we don’t do

– Byron Martina PhD

THE SIGNIFICANCE OF OUR RABIES RESEARCH PROJECTS

Rabies disease is a problem mainly in the rural areas of developing countries. It is important to realise that rabies NOT ONLY AFFECTS THE VICTIMS, but  the whole community and prevention of rabies has a huge financial and psychological impact. However, vaccination against rabies consists of a course of minimum three doses, costing between 160 euro and 400 euro per person. Knowing that a large proportion of the population in developing countries has less than 1 – 2 euro per day, it is understandable that most people cannot afford vaccination and rather spend their money on food. Therefore there is a pressing need to develop affordable and more effective vaccines for prevention of rabies disease and in addition antibodies to treat people that were exposed to the virus.

PROJECT 1: DEVELOPING “AFFORDABLE” VACCINE AND IMMUNOGLOBULIN

What is the significance of developing affordable vaccine and antibodies?

Availability of affordable vaccines and antibodies will SAVE THOUSANDS OF LIVES. This is definately possible if we invest in the development of a platform for easy, inexpensive, high quality and mass production of vaccines and immunoglobulins. Such a platform can also be used for production of vaccines and antibodies against other infectious diseases.

What are our goals?

DEVELOP CANDIDATE VACCINES AND ANTIBODIES THAT ARE MORE EFFECTIVE THAN CURRENTLY AVAILABLE ONES. It is a fact that the current vaccine is not potent in stimulating the immune response and therefore several doses of the vaccine must be administered. Our goal is to develop a much more potent vaccine for which only one administration is enough to provide protection.

PROJECT 2: DEVELOPING RABIES TREATMENT FOR “ALL”

What is the significance of developing a treatment?

For many vaccines it is an enormous effort to achieve high vaccine coverage in developing countries. It is therefore UNREALISTIC to expect everybody to be vaccinated. In addition, people coming from non-endemic areas are at risk of being infected with rabies. For these reasons IT IS OF PARAMOUNT IMPORTANCE TO HAVE MEDICINES THAT WE CAN USE TO TREAT SYMPTOMATIC PATIENTS THAT ARE TOO LATE TO RECEIVE THE VACCINE. Availability of such medicines may save the thousands of lives.

THE MISSION OF ARTEMIS ONE HEALTH:

Our mission is to make a DIFFERENCE in the lives of humans and animals by performing innovative and translational research, with the ultimate goal to develop SAFE, EFFECTIVE and AFFORDABLE vaccines against neglected infectious diseases.

Please support us

We encourage you to view some of the key problems in dealing with rabies versus the positive impact we envision on prevention and management of the disease.

 

SOME KEY PROBLEMS:

A. Lack of  rabies awareness

ARTEMIS’ POSITIVE ROLE: Artemis is committed to promote rabies awareness. For the next two years, we will design campaigns to increase awareness about the disease.

B. Limited affordability of vaccine for patients

ARTEMIS’ POSITIVE ROLE: Artemis is committed to develop affordable vaccines and antibodies that will save thousands of lives.

C. High costs related to vaccine usage
ARTEMIS’ POSITIVE ROLE: Artemis invests in the development of a platform for easy, inexpensive, high quality and mass production of vaccines and antibodies.
D. Complex vaccination schedule
ARTEMIS’ POSITIVE ROLE: Our goal is to develop a much more potent vaccine for which only one administration is enough to provide protection.
E. Lack of funding for rabies research
ARTEMIS’ POSITIVE ROLE: We will design charity campaigns to stimulate donations among the general public and philantropists in order to support preclinical research.
F. No demand for human rabies control. Priority is given to animal rabies control, because it is considered more effective
ARTEMIS’ POSITIVE ROLE: We focus on development of effective vaccines and medicines for use in humans, thereby complementing the effots of controlling rabies in animals and humans.

READ OUR

INTERVIEWS WITH RABIES EXPERTS

Our Head Research & Development, Dr. Byron Martina interviewed for this special occasion on “World Rabies Day”, 4 experts that have been working with rabies for more than a decade. In order to cover the different aspects and viewpoints in the problematics of the disease, we have selected experts with different backgrounds e.g veterinarian, infectious disease physician, consultant and research scientists.

Noel Tordo

Prof. dr. Noël Tordo

Directeur
Institut Pasteur de Guinée
Université Gamal Abdel Nasser – Conakry – Guinée
……………………………………………………………………………………………………………………………………………

Head, Antiviral Strategies Unit
WHO Collaborative Centre for Arboviruses and Viral Hemorrhagic Fevers
OIE Reference Laboratory for RVFV and CCHFV

DO YOU HAVE A PERSONAL EXPERIENCE WITH A RABIES VICTIM?

The only direct personal experience I have with a rabies victim is with the young American Jeanna, who survived rabies upon heavy treatment in 2005. I was…

Prof. Anthony. R. Fooks

Animal and Plant Health Agency (WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, OIE Reference Laboratory for Rabies), New Haw, Addlestone, Surrey, KT15 3NB, United Kingdom. Tel: +44 (0) 208-415-2238. Email: Tony.Fooks@apha.gsi.gov.uk
……………………………………………………………………………………………………………………………………………

BURDEN: THE GLOBAL BURDEN OF RABIES IS ESTIMATED TO BE AROUND 60,000 DEATHS PER YEAR. DO YOU THINK THE GLOBAL BURDEN OF RABIES MIGHT BE HIGHER?

The number of 60,000 cases is an estimate only and it can only be supposed that the number is an underestimate. My own research in collaboration with colleagues at the University of Liverpool in the UK and Malawi, demonstrated that clinical rabies in humans is often misdiagnosed. Post-mortems are rarely undertaken…

T.MuellerDr. Thomas Müller

 

Laborleiter
Institut für molekulare Virologie und Zellbiologie

……………………………………………………………………………………………………………………………………………
Friedrich-Loeffler-Institut
Bundesforschungsinstitut für Tiergesundheit
Federal Research Institute for Animal Health

DOGS ARE THE PROBLEM: SOME PEOPLE BELIEVE THAT IF WE ELIMATE RABIES FROM STRAYDOGS, RABIES WILL NO LONGER BE A PROBLEM. DO YOU THINK TARGETING STRAY DOGS IS THE WAY TO GO?

No. There is no evidence that stray dogs alone are responsible for maintaining the disease and that by solely focusing on this subpopulation the problem will be solved. This would be the wrong message. In my opinion…

Pieter van Thiel

Pieter van Thiel, MD. PhD

Infectious disease physician 
Academic Medical Center, University of Amsterdam, The Netherlands
……………………………………………………………………………………………………………………………………………

Honorary consultant Division of Infectious Diseases, Center for Tropical and Travel Medicine
Academic Medical Center, University of Amsterdam, The Netherlands
…………………………………………………………………………………………………………………………………
Hon.visiting physician Departm. of Medicine, College of Medicine, Univ. of Malawi, Blantyre, Malawi
AWARENESS: DO YOU THINK THERE IS A NEED TO INCREASE AWARENESS AMONG THE GENERAL POPULATION?

There is a great need to increase awareness under the population in the rural areas, e.g. posters in villages, messages via cell phones so that immediately after a likely rabies contact, a victim…

Rabies virus (orange) in a neuron

SUPPORT US

Rabies treatment for ALL! “Imagine” a world RABIES FREE.

Please support us

CHARITY PROJECT TWO

Rabies treatment for ALL; "IMAGINE", a future where rabies is treatable.

Rabies is the deadliest virus known to mankind. Some of the clinical manifestations of rabies include fear of water (hydrophobia) and air (aerophobia). Once a patient develops clinical disease, he/she will certainly die as a result of the infection. To date, 99.9% of infected individuals die of infection and this cannot be prevented. It is extremely important to have medicines to treat un vaccinated individuals, which is not only important to the developing countries where rabies is a real problem, but also to the developed countries where imported cases have been reported. Artemis One Health has used state-of-the-art technology to decipher some of the pathways involved in the pathogenic process of fatal rabies encephalitis. Furthermore, Artemis has discovered a protein that can naturally target the viral RNA and inhibit virus replication. In this project, Artemis will build on preliminary data and focus on optimising the specificity of the anti-rabies protein to eventually develop a safe and effective anti-rabies treatment.
Get INVOLVED

THANK YOU FOR BELIEVING IN US

WE WOULD LIKE TO THANK THE FOLLOWING INDIVIDUALS:

We thank Ab Osterhaus for narrating the story in our rabies film “Open Eyes”, Fungayi Mawire (mother role) and Sarah Jhingoerie (daughter role) for narrating a piece of the story in the rabies promotion film “Mother & Daughter”, and Wouter Mol for granting us permission to use part of his song track called Human in the rabies promotion film “Mother & Daughter”.

 

A very special thank you to our Head Research & Development, Dr. Byron Martina. This campaign would not have been possible without his advice and support.

 

 

Our Creative Team Collaborators

RABIES AWARENESS CAMPAIGN – 2017/2018

ARTEMIS ONE HEALTH RESEARCH FOUNDATION works with a group of Talented & Creative people, consisting of a webdesigner, a film producer, a photographer, a director, and a graphic designer. At Artemis we love creativity and innovation. We are always looking for new ideas and collaborators. Interested? Please feel free to contact Eurydice Martina, by email (e.martina@artemisonehealth.com) or phone (+31 306355444).

 

Claudia Bakker
Webdesigner & Founder of CBM webdesign

I have always had strong feelings about right and wrong. Especially if animals and innocent people (young children) are involved. We MUST put a stop on many diseases, just like Rabies. Working with Artemis gives me a chance to make a difference.

Eurydice Martina
Fundraising Officer at ARTEMIS & Founder of PROMAFUN Consultancy & Services

Every year, ~ 60,000 people die from rabies, a preventable disease. The majority of the victims are children in developing countries, who also had dreams.

As the director of this campaign, my focus was to deliver a strong message to the world, that every child is worth saving independent of where they live or their socio-economic status. No one in this world should die from a preventable disease!

Half of any battle is knowing when and how to fight. The best prevention of rabies is awareness of how to avoid danger and be prepared for when it hits.

Jasper Mol
Filmmaker & Founder Jasper Mol Productions

Young filmmaker and photographer from the Netherlands. Strives to touch and amaze.

Working with Artemis as a freelancer genuinely makes the best of two worlds. It’s an honor and a privilege to be part of the creative team that promotes rabies awareness during rabies world day.

Jeroen Roose
COO/ Head Technician at ARTEMIS

I am responsible for the functioning of the operational part of the research foundation. Furthermore, I focus on the technical aspect of the development of new technologies and provide the people in the lab with both scientific and technical support. Besides that, I think it is very important that vaccines against viruses such as rabies, should be available for everyone in the world and especially for children. Poverty may, in my opinion, never be the reason for not vaccinating children. It’s an honor and privilege to be also a part of the creative team, where I have the opportunity to design all the promotional material for all our campaigns.

Contact  Us

Let’s get in touch

Follow Us:

Where we are

Molengraaffsingel 10

2629 JD Delft

E: info@artemisonehealth.com

P: +31 (0)30 635 5444

Partner with us:

Contact our principle investigator, Dr. Byron Martina

E: b.martina@artemisonehealth.com

Send Us a Message

Thanks for your interest in Artemis One Health Research Foundation. Please feel free to contact us if you have any suggestions for research, questions about our projects or simply if you would like our advice. We respect your privacy and All information received will always remain confidential. We will try to respond to you within 3-5 working days. For urgent enquiries please call: +31 (0)30 635 5444.

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